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Reproductive history and fracture risk in postmenopausal women in a US national survey
  1. Prasanna Santhanam1,
  2. Steven P Rowe2,1,
  3. Lilja B Solnes3
  1. 1 Division of Nuclear Medicine and Molecular Imaging, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; psantha1@jhmi.edu
  2. 2 Division of Nuclear Medicine and Molecular Imaging, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; srowe8@jhmi.edu
  3. 3 Division of Nuclear Medicine and Molecular Imaging, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; lsolnes1@jhmi.edu
  1. Correspondence to Dr. Steven P Rowe; srowe8{at}jhmi.edu

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Estrogen promotes bone health, long-term replacement delaying osteoporosis,1 while sex steroids given for menstrual irregularity to premenopausal women increase bone mass.2 We therefore assessed the relation between reproductive health and fracture risk in postmenopausal women (≥50 years) in the US National Health and Nutrition Examination Survey (NHANES).3

In the 2013–2014 survey, fracture risk as FRAX scores4 was reported in an osteoporosis questionnaire with calculation of the 10-year risk of major hip fracture. We collected data on the age at last menstrual period, last live birth, and first live birth as continuous variables, and documented history of pregnancy …

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